Ainsliadimer A, a new sesquiterpene lactone dimer with an unusual carbon skeleton from Ainsliaea macrocephala

  • Org Lett. 2008 Jun 19;10(12):2397-400. doi: 10.1021/ol800656q.
Zhi-Jun Wu  1 ,  Xi-Ke Xu ,  Yun-Heng Shen ,  Juan Su ,  Jun-Mian Tian ,  Shuang Liang ,  Hui-Liang Li ,  Rui-Hui Liu ,  Wei-Dong Zhang
Affiliations
  • 1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
PMID: 18484734 DOI: 10.1021/ol800656q
Abstract

A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.

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