3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors

  • Bioorg Med Chem Lett. 2008 Jun 1;18(11):3158-62. doi: 10.1016/j.bmcl.2008.04.075.
Matthias Eckhardt  1 ,  Norbert Hauel ,  Frank Himmelsbach ,  Elke Langkopf ,  Herbert Nar ,  Michael Mark ,  Moh Tadayyon ,  Leo Thomas ,  Brian Guth ,  Ralf Lotz
Affiliations
  • 1. Department of Chemical Research, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany. [email protected]
PMID: 18485703 DOI: 10.1016/j.bmcl.2008.04.075
Abstract

Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.