Cytotoxic dihydroagarofuranoid sesquiterpenes from the seeds of Celastrus orbiculatus

  • J Nat Prod. 2008 Jun;71(6):1005-10. doi: 10.1021/np800052d.
Yingdong Zhu  1 ,  Zehong Miao ,  Jian Ding ,  Weimin Zhao
Affiliations
  • 1. Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 18507472 DOI: 10.1021/np800052d
Abstract

A chemical study on the seeds of Celastrus orbiculatus has led to the isolation of nine new (1- 9) and 13 known dihydro-beta-agarofuran derivatives. The identification and structural elucidation of the new compounds were based on spectroscopic data analysis, and the absolute configurations of compounds 1- 6, 8-10, and 16, as well as derivatives 2a and 6a, were determined by CD studies or by chemical methods. All compounds isolated were evaluated for cytotoxic activity against HL-60 human leukemia cells.