BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis

  • Planta Med. 2008 Apr;74(5):540-5. doi: 10.1055/s-2008-1074496.
Liang Lv  1 ,  Qing-Yun Yang ,  Ying Zhao ,  Chun-Suo Yao ,  Yang Sun ,  Eun-Ju Yang ,  Kyung-Sik Song ,  Inhee Mook-Jung ,  Wei-Shuo Fang
Affiliations
  • 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Beijing, P. R. China.
PMID: 18543151 DOI: 10.1055/s-2008-1074496
Abstract

Four new chromone glycosides allo-aloeresin D (2) , C-2'-decoumaroyl-aloeresin G (8), 2'-O-coumaroyl-(S)-aloesinol (9), 2'-O-[ P-methoxy-(E)-cinnamoyl]-(S)-aloesinol (10) and nine known chromone glycosides ( 1, 3 - 7, 11 - 13) were isolated from two Aloe spp. Plants, A. vera and A. nobilis. Among them, 1 and 8 showed significant inhibitory activity against BACE1 (Beta-secretase) with IC (50) values of 39.0 and 20.5 x 10 (-6) M, as well as inhibition of Abeta (1-42) production by 7.4 and 12.3 %, respectively, in B103 neuroblastoma cells at 30 ppm. The preliminary structure-activity relationships of ALOE chromone glucosides were also discussed.

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