Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length

  • Bioorg Med Chem Lett. 2008 Jul 15;18(14):4249-52. doi: 10.1016/j.bmcl.2008.02.020.
Shuichi Mori  1 ,  Shinya Miyake ,  Takayoshi Kobe ,  Takaaki Nakaya ,  Stephen D Fuller ,  Nobuo Kato ,  Kunihiro Kaihatsu
Affiliations
  • 1. The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
PMID: 18547804 DOI: 10.1016/j.bmcl.2008.02.020
Abstract

A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG.