Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea

  • J Nat Prod. 2008 Jul;71(7):1173-7. doi: 10.1021/np800055q.
Sompong Boonsri  1 ,  Chatchanok Karalai ,  Chanita Ponglimanont ,  Suchada Chantrapromma ,  Akkharawit Kanjana-Opas
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
PMID: 18553924 DOI: 10.1021/np800055q
Abstract

Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four Cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their Antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented.