Macaflavanones A-G, prenylated flavanones from the leaves of Macaranga tanarius

  • J Nat Prod. 2008 Nov;71(11):1872-6. doi: 10.1021/np800380d.
Shiori Kawakami  1 ,  Liva Harinantenaina ,  Katsuyoshi Matsunami ,  Hideaki Otsuka ,  Takakazu Shinzato ,  Yoshio Takeda
Affiliations
  • 1. Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
PMID: 18844422 DOI: 10.1021/np800380d
Abstract

Phytochemical investigation of leaves of Macaranga tanarius resulted in the isolation of seven new prenylated flavanones, macaflavanones A-G (1-7), along with two known compounds, nymphaeol C (9) and the diterpene kolavenol. The structures of the new compounds were elucidated by means of a combination of spectroscopic methods and chemical conversion. The absolute structure of tanariflavanone B (8), isolated from the title plant, was also resolved. The cytotoxic activities of isolated flavanones were assayed using two cell lines, with macaflavanone G (7) being the most active compound in each case.