Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis

  • Arch Pharm Res. 1997 Dec;20(6):633-6. doi: 10.1007/BF02975223.
I S Lee  1 ,  K Y Jung ,  S R Oh ,  D S Kim ,  J H Kim ,  J J Lee ,  H K Lee ,  S H Lee ,  E H Kim ,  C Cheong
Affiliations
  • 1. Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong, P.O. Box 115, 305-600, Taejon, Korea.
PMID: 18982271 DOI: 10.1007/BF02975223
Abstract

In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.

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