Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens

  • Bioorg Med Chem. 2009 Feb 15;17(4):1636-9. doi: 10.1016/j.bmc.2008.12.057.
Angela Bassoli  1 ,  Gigliola Borgonovo ,  Sara Caimi ,  Leonardo Scaglioni ,  Gabriella Morini ,  Aniello Schiano Moriello ,  Vincenzo Di Marzo ,  Luciano De Petrocellis
Affiliations
  • 1. DISMA, Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Milano, Italy. [email protected]
PMID: 19162486 DOI: 10.1016/j.bmc.2008.12.057
Abstract

Perilla frutescens is a food plant widely used in Asian cuisine. This plant was investigated for its interesting taste and somatosensory properties. Perillaldehyde and perillaketone are among the components of the aromatic extracts from P. Frutescens. These compounds were shown here to activate the cloned TRPA1 channel when expressed in an heterologous cell system and are therefore suggested to be responsible for the chemesthetic properties of this plant.