Total synthesis of amidepsine B and revision of its absolute configuration

  • J Antibiot (Tokyo). 2009 Feb;62(2):69-74. doi: 10.1038/ja.2008.12.
Tohru Nagamitsu  1 ,  Kaori Marumoto ,  Asami Nagayasu ,  Takeo Fukuda ,  Shiho Arima ,  Ryuji Uchida ,  Taichi Ohshiro ,  Yoshihiro Harigaya ,  Hiroshi Tomoda ,  Satoshi Omura
Affiliations
  • 1. School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan.
PMID: 19198634 DOI: 10.1038/ja.2008.12
Abstract

The total synthesis of (-)-amidepsine B, a potent diacylglycerol Acyltransferase Inhibitor, has been achieved. This synthetic study resulted in the revision of the previously assigned stereostructure of the natural amidepsine B and determined the absolute configuration.

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