Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine

  • Bioorg Med Chem. 2009 Mar 15;17(6):2321-6. doi: 10.1016/j.bmc.2009.02.011.
Marie Hamann  1 ,  Claire Pierra ,  Jean-Pierre Sommadossi ,  Chiara Musiu ,  Luana Vargiu ,  Michel Liuzzi ,  Richard Storer ,  Gilles Gosselin
Affiliations
  • 1. Idenix Pharmaceuticals, Medicinal Chemistry Laboratories IDENIX Sarl, Cap Gamma, 1682 rue de la Valsière, 34189 Montpellier Cedex 4, France.
PMID: 19254848 DOI: 10.1016/j.bmc.2009.02.011
Abstract

Several thieno[3,4-d]pyrimidine derivatives, including four hitherto unknown 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in Cell Culture experiments against human immunodeficiency virus, none of the tested compounds exhibited any significant Antiviral effect, while two of them showed some cytotoxicity.