Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

  • Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. doi: 10.1016/j.bmcl.2009.02.077.
Stefano Pegoraro  1 ,  Martin Lang ,  Tobias Dreker ,  Jürgen Kraus ,  Svetlana Hamm ,  Cathal Meere ,  Juliane Feurle ,  Stefan Tasler ,  Sylvia Prütting ,  Zerrin Kuras ,  Violeta Visan ,  Stephan Grissmer
Affiliations
  • 1. 4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.
PMID: 19282171 DOI: 10.1016/j.bmcl.2009.02.077
Abstract

New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.