Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety

  • Bioorg Med Chem Lett. 2009 Apr 15;19(8):2263-5. doi: 10.1016/j.bmcl.2009.02.092.
Haolun Jin  1 ,  Sammy Metobo ,  Salman Jabri ,  Michael Mish ,  Rachael Lansdown ,  Xiaowu Chen ,  Manuel Tsiang ,  Matthew Wright ,  Choung U Kim
Affiliations
PMID: 19285389 DOI: 10.1016/j.bmcl.2009.02.092
Abstract

SAR studies on the para-fluorobenzyl moiety of tricyclic HIV Integrase inhibitors are discussed and lead compounds with potency and PK properties comparable to raltegravir were identified.