Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus

  • Bioorg Med Chem. 2009 Apr 15;17(8):3025-7. doi: 10.1016/j.bmc.2009.03.022.
Christopher McGuigan  1 ,  Olivier Bidet ,  Marco Derudas ,  Graciela Andrei ,  Robert Snoeck ,  Jan Balzarini
Affiliations
  • 1. Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK. [email protected]
PMID: 19328697 DOI: 10.1016/j.bmc.2009.03.022
Abstract

Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta-alkenyl systems lose 3-4 orders of potency.