A new psoralen derivative with enlarged antiproliferative properties

  • Bioorg Med Chem Lett. 2009 May 15;19(10):2874-6. doi: 10.1016/j.bmcl.2009.03.073.
Lisa Dalla Via  1 ,  Jose Carlos González-Gómez ,  Lázaro Guillermo Pérez-Montoto ,  Lourdes Santana ,  Eugenio Uriarte ,  Sebastiano Marciani Magno ,  Ornella Gia
Affiliations
  • 1. Department of Pharmaceutical Sciences, University of Padova, Italy.
PMID: 19359172 DOI: 10.1016/j.bmcl.2009.03.073
Abstract

Following our results with benzopsoralens as potent photochemotherapeutic agents, we report the antiproliferative evaluation of nitrogenated isoster upon and without UVA irradiation. The evaluated pyridazinopsoralen showed a higher photochemotherapeutic activity with respect to the well-known drug, 8-MOP, and a significant cytotoxicity, also in the dark. This result enlarges the interest in this tetracyclic psoralen derivative skeleton in the search of new Anticancer agents.