Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

  • J Microbiol Biotechnol. 2009 Apr;19(4):368-71. doi: 10.4014/jmb.0806.389.
Soo-Jin Choo  1 ,  Bong-Sik Yun ,  In-Ja Ryoo ,  Young-Hee Kim ,  Ki-Hwan Bae ,  Ick-Dong Yoo
Affiliations
  • 1. Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
PMID: 19420992 DOI: 10.4014/jmb.0806.389
Abstract

In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 microM without cytotoxicity.

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