Aspochalasin I
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent.
For research use only. We do not sell to patients.
- CAS No.: 670225-69-1
- Formula: C24H35NO5
- Molecular Weight:417.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>20 μM
Compound: 6
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Cytotoxicity against human A2780 cells by MTT assay
Cytotoxicity against human A2780 cells by MTT assay
|
[PMID: 39258410] |
| HeLa | IC50 |
>20 μM
Compound: 6
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Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
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[PMID: 39258410] |
| HepG2 | IC50 |
>20 μM
Compound: 6
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 39258410] |
| MCF7 | IC50 |
33.4 μM
Compound: 1, aspochalasin I
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 15043404] |
| NCI-H460 | IC50 |
22.1 μM
Compound: 1, aspochalasin I
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Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
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[PMID: 15043404] |
| SF-268 | IC50 |
19.9 μM
Compound: 1, aspochalasin I
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Cytotoxicity against human SF268 cells after 48 hrs by MTT assay
Cytotoxicity against human SF268 cells after 48 hrs by MTT assay
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[PMID: 15043404] |
| SK-OV-3 | IC50 |
>20 μM
Compound: 6
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Cytotoxicity against human SK-OV-3 cells by MTT assay
Cytotoxicity against human SK-OV-3 cells by MTT assay
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[PMID: 39258410] |
Chemical Information
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CAS No. 670225-69-1
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Molecular Weight 417.54
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Formula C24H35NO5
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SMILES
CC1=C[C@@](/C=C(C)/CC[C@H](O)[C@H](O)/C=C/2)([H])[C@@]3(OC2=O)[C@@]([C@H](CC(C)C)NC3=O)([H])[C@@H]1C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Choo SJ, et al., Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp. J Microbiol Biotechnol. 2009 Apr;19(4):368-71 [Content Brief]
[2]. Zhou GX, et al., Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert. J Nat Prod. 2004 Mar;67(3):328-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aspochalasin I Related Classifications
HY-126618 Related Classifications
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