Isocoumarin glucosides from the scale insect fungus Torrubiella tenuis BCC 12732

  • J Nat Prod. 2009 Jul;72(7):1341-3. doi: 10.1021/np900082h.
Jittra Kornsakulkarn  1 ,  Chawanee Thongpanchang ,  Sanisa Lapanun ,  Kitlada Srichomthong
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology, Klong Luang, Pathumthani 12120, Thailand.
PMID: 19456117 DOI: 10.1021/np900082h
Abstract

Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3-methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 5 exhibited moderate anti-HSV-1 and antimycobacterial activities with IC(50) and MIC values of 50 and 25 microg/mL, respectively.