Aminoquinoline derivatives with antiproliferative activity against melanoma cell line
- Bioorg Med Chem Lett. 2009 Jul 1;19(13):3517-20. doi: 10.1016/j.bmcl.2009.05.007.
Affiliations
- 1. Life Sciences Research Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
PMID: 19464887
DOI: 10.1016/j.bmcl.2009.05.007
Abstract
The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC(50)=0.77 and 0.79microM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.