Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening

  • Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. doi: 10.1016/j.bmc.2009.05.083.
Hendra Gunosewoyo  1 ,  Mark J Coster ,  Maxwell R Bennett ,  Michael Kassiou
Affiliations
  • 1. School of Chemistry, University of Sydney, NSW 2006, Australia.
PMID: 19540765 DOI: 10.1016/j.bmc.2009.05.083
Abstract

The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.