Bioactive Nortriterpenoids from Schisandra grandiflora

  • J Nat Prod. 2009 Sep;72(9):1678-81. doi: 10.1021/np900292e.
Wei-Lie Xiao  1 ,  Yan-Qing Gong ,  Rui-Rui Wang ,  Zhi-Ying Weng ,  Xiao Luo ,  Xiao-Nian Li ,  Guang-Yu Yang ,  Fei He ,  Jian-Xin Pu ,  Liu-Meng Yang ,  Yong-Tang Zheng ,  Yang Lu ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
PMID: 19685905 DOI: 10.1021/np900292e
Abstract

Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human Cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.