Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses

  • Bioorg Med Chem Lett. 2009 Oct 1;19(19):5689-92. doi: 10.1016/j.bmcl.2009.08.009.
Kristjan S Gudmundsson  1 ,  Brian A Johns ,  Jason Weatherhead
Affiliations
  • 1. Department of Medicinal Chemistry, Metabolic and Virology Center of Excellence for Drug Discovery, GlaxoSmithKline Research & Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. [email protected]
PMID: 19700316 DOI: 10.1016/j.bmcl.2009.08.009
Abstract

Synthesis of several pyrazolo[1,5-c]pyrimidines, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in Antiviral activity are highlighted. Several compounds with in vitro Antiviral activity similar or better than acyclovir are described.