Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum

  • J Nat Prod. 2009 Oct;72(10):1879-83. doi: 10.1021/np9003849.
Intan Safinar Ismail  1 ,  Yuta Nagakura ,  Yusuke Hirasawa ,  Takahiro Hosoya ,  Mohd Izwan Mohd Lazim ,  Nordin Hj Lajis ,  Motoo Shiro ,  Hiroshi Morita
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
PMID: 19757855 DOI: 10.1021/np9003849
Abstract

Four new chromone Alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon Cancer cells.