Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

  • Bioorg Med Chem Lett. 2009 Nov 15;19(22):6303-6. doi: 10.1016/j.bmcl.2009.09.093.
Mankil Jung  1 ,  Namsoo Park ,  Hyung-In Moon ,  Yongnam Lee ,  Won-Yoon Chung ,  Kwang-Kyun Park
Affiliations
  • 1. Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea. [email protected]
PMID: 19819696 DOI: 10.1016/j.bmcl.2009.09.093
Abstract

Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro Anticancer activity against major human Cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.