New small molecule inhibitors of hepatitis C virus

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):6926-30. doi: 10.1016/j.bmcl.2009.10.070.
Wanguo Wei  1 ,  Cuifang Cai ,  Smitha Kota ,  Virginia Takahashi ,  Feng Ni ,  A Donny Strosberg ,  John K Snyder
Affiliations
  • 1. Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
PMID: 19896376 DOI: 10.1016/j.bmcl.2009.10.070
Abstract

New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.