Neolignans from Piper kadsura and their anti-neuroinflammatory activity

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):409-12. doi: 10.1016/j.bmcl.2009.10.016.
Ki Hyun Kim  1 ,  Jung Wook Choi ,  Sang Keun Ha ,  Sun Yeou Kim ,  Kang Ro Lee
Affiliations
  • 1. Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea.
PMID: 19900811 DOI: 10.1016/j.bmcl.2009.10.016
Abstract

Bioassay-guided column chromatographic separation of the methanolic extract of dried aerial parts of Piper kadsura (Piperaceae) led to the isolation of a new neolignan, piperkadsin C (1), together with eight known neolignans (2-9). The structures of the isolated compounds were elucidated by combined spectroscopic methods. The anti-neuroinflammatory activities of these compounds were evaluated by assessing nitric oxide (NO) production in LPS-activated BV-2 cells, a microglia cell line. Piperkadsin C (1) and futoquinol (2) potently inhibited NO production with an IC(50) value of 14.6 and 16.8microM in microglia cells, respectively. Compounds 3, 4, 5, 8, and 9 also exhibited moderate inhibition of NO production in BV-2 cells.

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