Review of 5-HT4R ligands: state of art and clinical applications

  • Curr Top Med Chem. 2010;10(5):527-53. doi: 10.2174/156802610791111551.
Ronan Bureau  1 ,  Michel Boulouard ,  François Dauphin ,  Frank Lezoualc'h ,  Sylvain Rault
Affiliations
  • 1. Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN) UPRES EA 4258, FR CNRS 3038, Université de Caen, Boulevard Becquerel, 14032 Caen, France. [email protected]
PMID: 20166943 DOI: 10.2174/156802610791111551
Abstract

This article reviews the medicinal implications of 5-HT(4)R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT(4)R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.

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