Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica

  • J Nat Prod. 2010 Apr 23;73(4):557-62. doi: 10.1021/np900620y.
Li-Jie Zhang  1 ,  Chun-Tang Chiou ,  Jing-Jy Cheng ,  Hui-Chi Huang ,  Li-Ming Yang Kuo ,  Chia-Chin Liao ,  Kenneth F Bastow ,  Kuo-Hsiung Lee ,  Yao-Haur Kuo
Affiliations
  • 1. National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China.
PMID: 20232858 DOI: 10.1021/np900620y
Abstract

Six new polyisoprenyl benzophenonoids, (+/-)-garcinialiptone A (1, 2), garcinialiptone B (3), (-)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1-6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).