An unprecedented biogenetic-type chemical synthesis of 1(15-->11) abeotaxanes from normal taxanes

  • J Nat Prod. 2010 Apr 23;73(4):747-50. doi: 10.1021/np900722j.
T Narender  1 ,  K Papi Reddy ,  V K Singh ,  K Rajendar ,  J Sarkar
Affiliations
  • 1. Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow-226 001, U.P., India. [email protected]
PMID: 20302348 DOI: 10.1021/np900722j
Abstract

A one-pot chemical process using BF(3).Et(2)O for the synthesis of a new class of 1(15-->11) abeotaxanes from normal taxanes has been developed. The chemical structures of rearranged 1(15-->11) abeotaxane were established by extensive 2D NMR spectroscopic data.