Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases

  • Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5. doi: 10.1016/j.bmcl.2010.03.015.
Steve D Fidanze  1 ,  Scott A Erickson ,  Gary T Wang ,  Robert Mantei ,  Richard F Clark ,  Bryan K Sorensen ,  Nwe Y Bamaung ,  Peter Kovar ,  Eric F Johnson ,  Kerren K Swinger ,  Kent D Stewart ,  Qian Zhang ,  Lora A Tucker ,  William N Pappano ,  Julie L Wilsbacher ,  Jieyi Wang ,  George S Sheppard ,  Randy L Bell ,  Steven K Davidsen ,  Robert D Hubbard
Affiliations
  • 1. Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. [email protected]
PMID: 20346655 DOI: 10.1016/j.bmcl.2010.03.015
Abstract

The design and enzyme activities of a novel class of imidazo[2,1-b]thiazoles is presented.