Chemoselective coupling reactions of 5,7-dimethoxyphthalide with the remotely functionalized alkyl iodides: facile racemic synthesis of Helicobacter pylori antibiotics

  • J Org Chem. 2010 May 7;75(9):3121-4. doi: 10.1021/jo100168f.
Mandeep Singh  1 ,  Narshinha P Argade
Affiliations
  • 1. Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411 008, India.
PMID: 20377262 DOI: 10.1021/jo100168f
Abstract

Highly chemoselective coupling reactions of 5,7-dimethoxyphthalide carbanion with the remotely functionalized long chain alkyl iodides have been demonstrated to accomplish the concise and efficient synthesis of Helicobacter pylori Antibiotics, the CJ-molecules, and sporotricale methyl ether.

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