Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2722-5. doi: 10.1016/j.bmcl.2010.03.078.
William M Robertson  1 ,  David B Kastrinsky ,  Inkyu Hwang ,  Dale L Boger
Affiliations
  • 1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 20381346 DOI: 10.1016/j.bmcl.2010.03.078
Abstract

The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described.