Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida

  • J Nat Prod. 2010 May 28;73(5):949-55. doi: 10.1021/np1002065.
Yulin Ren  1 ,  Leonardus B S Kardono ,  Soedarsono Riswan ,  Heebyung Chai ,  Norman R Farnsworth ,  Djaja D Soejarto ,  Esperanza J Carcache de Blanco ,  A Douglas Kinghorn
Affiliations
  • 1. Division of Medicinal Chemistry and Pharmacognosy and Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
PMID: 20384315 DOI: 10.1021/np1002065
Abstract

Four new prenylated Flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic toward HT-29 human colon Cancer cells, with the most potent being compound 2 and the known compounds 6 and 8. Of the substances obtained, compounds 1 and 7 were the most active in the NF-kappaB p50 and p65 assay, respectively.