Synthesis and antitumor activity of new shikonin glycosides

  • Eur J Med Chem. 2010 Jul;45(7):2713-8. doi: 10.1016/j.ejmech.2010.02.002.
Yehua Su  1 ,  Jiansheng Xie ,  Yanguang Wang ,  Xun Hu ,  Xianfu Lin
Affiliations
  • 1. Department of Chemistry, Zhejiang University, 38# Zheda Road, Hangzhou 310027, PR China.
PMID: 20403646 DOI: 10.1016/j.ejmech.2010.02.002
Abstract

Eleven shikonin glycosides were synthesized and evaluated for their antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug sensitive cell lines (K562, MCF-7 and HL60) and their drug resistant cell sublines (K562/ADR, MCF-7/ADR and HL60/ADR).