Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis

  • J Nat Prod. 2010 Jun 25;73(6):1112-6. doi: 10.1021/np100110u.
Xiao Luo  1 ,  Jian-Xin Pu ,  Wei-Lie Xiao ,  Yong Zhao ,  Xue-Mei Gao ,  Xiao-Nian Li ,  Hai-Bo Zhang ,  Yuan-Yuan Wang ,  Yan Li ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 20521771 DOI: 10.1021/np100110u
Abstract

Ten new ent-kaurane Diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human Cancer cell lines, and some exhibited quite potent inhibitory activities.