Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates

  • Antimicrob Agents Chemother. 2010 Sep;54(9):3974-7. doi: 10.1128/AAC.00484-10.
Michelle M Butler  1 ,  John D Williams ,  Norton P Peet ,  Donald T Moir ,  Rekha G Panchal ,  Sina Bavari ,  Dean L Shinabarger ,  Terry L Bowlin
Affiliations
  • 1. Microbiotix, Inc., One Innovation Drive, Worcester, MA 01605, USA. [email protected]
PMID: 20625154 DOI: 10.1128/AAC.00484-10
Abstract

Antimicrobial susceptibilities of 233 gram-positive and 180 gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 microg/ml. One bis-indole, MBX 1162, exhibited potent activity against all gram-negative strains, with MIC(90) values of 0.12 to 4 microg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator Antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.