Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica

  • J Nat Prod. 2010 Aug 27;73(8):1448-52. doi: 10.1021/np100325q.
Giuseppina Chianese  1 ,  Serge R Yerbanga ,  Leonardo Lucantoni ,  Annette Habluetzel ,  Nicoletta Basilico ,  Donatella Taramelli ,  Ernesto Fattorusso ,  Orazio Taglialatela-Scafati
Affiliations
  • 1. Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131, Napoli, Italy.
PMID: 20669933 DOI: 10.1021/np100325q
Abstract

Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.

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