Eucophylline, a Tetracyclic Vinylquinoline Alkaloid from Leuconotis eugenifolius

  • J Nat Prod. 2010 Oct 22;73(10):1727-9. doi: 10.1021/np100458b.
Jun Deguchi  1 ,  Tomokazu Shoji ,  Alfarius E Nugroho ,  Yusuke Hirasawa ,  Takahiro Hosoya ,  Osamu Shirota ,  Khalijah Awang ,  A Hamid A Hadi ,  Hiroshi Morita
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
PMID: 20836516 DOI: 10.1021/np100458b
Abstract

Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.