Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives

  • Bioorg Med Chem Lett. 2010 Nov 1;20(21):6324-6. doi: 10.1016/j.bmcl.2010.06.001.
Mehul M Patel  1 ,  Mimansha D Mali ,  Saurabh K Patel
Affiliations
  • 1. Chemistry Research laboratory, Department of Chemistry, Veer Narmad South Gujarat University, Surat 395 007, Gujarat, India.
PMID: 20850303 DOI: 10.1016/j.bmcl.2010.06.001
Abstract

The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro Antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram +ve), Escherichia coli, Pseudomonas aeruginosa (gram -ve) and Antifungal activity against Aspergillus niger and Anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and Anticancer activity with IC(50) values in the low micromolar range.