Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

  • Chem Commun (Camb). 2010 Nov 14;46(42):8020-2. doi: 10.1039/c0cc02969f.
Jason R Porter  1 ,  Mark R Helmers ,  Ping Wang ,  Jennifer L Furman ,  Stephen T Joy ,  Paramjit S Arora ,  Indraneel Ghosh
Affiliations
  • 1. Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Blvd, Tucson, AZ 85721, USA.
PMID: 20856941 DOI: 10.1039/c0cc02969f
Abstract

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

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