Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea

  • Planta Med. 2011 Mar;77(4):377-9. doi: 10.1055/s-0030-1250384.
Bruno Ndjakou Lenta  1 ,  Louis Marie Kamdem ,  Silvère Ngouela ,  Ferdinand Tantangmo ,  Krishna Prasad Devkota ,  Fabrice Fekam Boyom ,  Philip John Rosenthal ,  Etienne Tsamo
Affiliations
  • 1. Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon.
PMID: 20927694 DOI: 10.1055/s-0030-1250384
Abstract

Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (-)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 1- 3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC₅₀ values below 3 µM.

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