Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava

  • Org Lett. 2010 Nov 5;12(21):5040-3. doi: 10.1021/ol102179u.
Meng Shao  1 ,  Ying Wang ,  Zhong Liu ,  Dong-Mei Zhang ,  Hui-Hui Cao ,  Ren-Wang Jiang ,  Chun-Lin Fan ,  Xiao-Qi Zhang ,  He-Ru Chen ,  Xin-Sheng Yao ,  Wen-Cai Ye
Affiliations
  • 1. Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
PMID: 20929258 DOI: 10.1021/ol102179u
Abstract

Psiguadials A (1) and B (2), two novel sesquiterpenoid-diphenylmethane meroterpenoids with unusual skeletons, along with a pair of known epimers, psidial A (3) and guajadial (4), were isolated from the leaves of Psidium guajava. Their structures with absolute configurations were elucidated by means of NMR, X-ray diffraction, and quantum chemical CD calculation. Compounds 1, 2, and 4 exhibited potent inhibitory effects on the growth of human hepatoma cells.

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