Termitomycamides A to E, fatty acid amides isolated from the mushroom Termitomyces titanicus, suppress endoplasmic reticulum stress

  • Org Lett. 2010 Nov 5;12(21):5012-5. doi: 10.1021/ol102186p.
Jae-Hoon Choi  1 ,  Kohei Maeda ,  Kaoru Nagai ,  Etsuko Harada ,  Mitsuo Kawade ,  Hirofumi Hirai ,  Hirokazu Kawagishi
Affiliations
  • 1. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
PMID: 20936815 DOI: 10.1021/ol102186p
Abstract

Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1-5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum stress-dependent cell death.

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