Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes

  • J Antibiot (Tokyo). 2011 Jan;64(1):45-9. doi: 10.1038/ja.2010.128.
Shu-Ming Li  1
Affiliations
  • 1. Philipps-Universität Marburg, Institut für Pharmazeutische Biologie und Biotechnologie, Marburg, Germany. [email protected]
PMID: 21063425 DOI: 10.1038/ja.2010.128
Abstract

This review summarizes the recent progress on the biosynthesis of fumitremorgin-type alkaloids; that is, the identification of the biosynthetic gene clusters from genome sequences by genome mining and proof of gene function by molecular biological and biochemical investigations.

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