Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

  • Eur J Med Chem. 2011 Jan;46(1):417-22. doi: 10.1016/j.ejmech.2010.11.014.
Yu Luo  1 ,  Feng Xiao ,  Shijing Qian ,  Wei Lu ,  Bo Yang
Affiliations
  • 1. Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
PMID: 21115212 DOI: 10.1016/j.ejmech.2010.11.014
Abstract

A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro Anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.