Glycosylated nordihydroguaiaretic acids as anti-cancer agents
- Bioorg Med Chem Lett. 2011 Jan 1;21(1):380-2. doi: 10.1016/j.bmcl.2010.10.137.
Affiliations
- 1. Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC. [email protected]
PMID: 21123067
DOI: 10.1016/j.bmcl.2010.10.137
Abstract
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.