Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry

  • J Med Chem. 2011 Mar 24;54(6):1539-54. doi: 10.1021/jm101356p.
Minoru Ishikawa  1 ,  Yuichi Hashimoto
Affiliations
  • 1. Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. [email protected]
PMID: 21344906 DOI: 10.1021/jm101356p