A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

  • Bioorg Med Chem Lett. 2011 Mar 15;21(6):1792-4. doi: 10.1016/j.bmcl.2011.01.067.
Yu-Ming Chung  1 ,  Fang-Rong Chang ,  Tseng-Fu Tseng ,  Tsong-Long Hwang ,  Lei-Chin Chen ,  Shou-Fang Wu ,  Chia-Lin Lee ,  Zu-Yau Lin ,  Li-Yeh Chuang ,  Jinu-Huang Su ,  Yang-Chang Wu
Affiliations
  • 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
PMID: 21353775 DOI: 10.1016/j.bmcl.2011.01.067
Abstract

A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on Elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and Elastase release with IC(50) values of 0.12 and 0.20 μg/mL, respectively.

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