A comprehensive investigation of anti-inflammatory diarylheptanoids from the leaves of Alnus formosana

  • Phytochemistry. 2012 Jan;73(1):84-94. doi: 10.1016/j.phytochem.2011.02.008.
Yi-Chun Lai  1 ,  Chien-Kuang Chen ,  Wan-Wan Lin ,  Shoei-Sheng Lee
Affiliations
  • 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
PMID: 21388646 DOI: 10.1016/j.phytochem.2011.02.008
Abstract

This study was aimed to investigate thoroughly the diarylheptanoids in the n-BuOH soluble fraction of leaves of Alnus formosana in order to examine their anti-inflammatory activities. The application of HPLC-SPE-NMR as a preliminary chemical screening led to characterization of eleven compounds. Further separation resulted in isolation of 28 compounds, of which 10 diarylheptanoids and 2-coumaroylxyloside are new natural products. Compound 1 and alnuside A (27) were found to possess good activities against LPS-induced NO production with respective IC(50) values of 7.99 and 8.08 μM, and which were devoid of significant cytotoxicity.

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