Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

  • Bioorg Med Chem. 2011 Apr 1;19(7):2450-7. doi: 10.1016/j.bmc.2011.02.002.
Yutaka Aoyagi  1 ,  Yoshiyuki Adachi ,  Kei Ozawa ,  Chihiro Yokomizo ,  Ming-Yu Gui ,  Yong-Ri Jin ,  Xu-Wen Li ,  Naohito Ohno ,  Koichi Takeya
Affiliations
  • 1. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 21393004 DOI: 10.1016/j.bmc.2011.02.002
Abstract

A series of rabdokunmin C analogues were prepared and their inhibitory effect on NF-κB activation was assayed. One of them, 18-acetyl-12-deoxy-11,12-dehydrorabdokunmin C (16) was found to be a promising candidate for an anti-inflammatory agent.